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Chagas' Disease and the Nervous System

$22.00 Latin America and the Caribbean / $30.00 Elsewhere

Out of print
This book is now out-of-print.To find this book, we advise that you to visit a PAHO Publications Center or the Documentation Center of the PAHO Field Office in your country. We welcome requests to reprint.


Order code: SP 547

This publication presents an up-to-date and in-depth review of the effects of Chagas' disease on the nervous system—from the alterations seen in patients to the mechanisms by which the pathology is produced—and, in doing so, it highlights the ways this knowledge was painstakingly acquired.

The book begins with an overview of the extent of the health problems posed by Chagas' disease (also known as American trypanosomiasis) and how they are being addressed through improved diagnosis and multifaceted research. The next section describes studies of specific alterations in autonomic, peripheral, and central nervous functions produced by chagasic infections in humans, including children suffering from congenital infection. The third section presents findings on the role played by the body's immune response to the parasite in the genesis of nervous tissue lesions. The final two chapters discuss studies of nervous system pathology in two experimental models, mice and monkeys, and how they can enhance understanding of the infection in humans.

Leading experts in the field of Chagas' disease research contributed the 19 chapters in this volume. Researchers in immunology, neurology, and parasitic diseases will find this book to be a compendium of state-of-the-art knowledge; physicians and other health professionals will gain valuable insight on the condition of patients afflicted with this widespread parasitosis.

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